Progesterone shown to reduce risk of miscarriage in some women

Published on: 22/05/2019

A large study has found that giving women the hormone Progesterone, who have recently suffered from miscarriages, can improve their chances of having a full term pregnancy and a healthy baby.

What is Progesterone?

Progesterone is a hormone that is essential in pregnancy, for maintaining the lining of the womb where the embryo is implanted, and supporting the immune system. Miscarriage affects 1 in 5 women, and vaginal bleeding in early pregnancy is linked to an increased risk in miscarriage happening. It is hoped that the further research into the hormone will help to make more miscarriages preventable.

The PRISM Trial

This was the largest trial of it’s kind and involved just over 4000 pregnant women who presented with early pregnancy bleeding. It was funded by the National Institute of Health Research, and co-ordinated in the University of Birmingham in collaboration with Tommy’s National Centre for Miscarriage Research. The women were treated at 48 hospitals across the UK and placed into 2 groups, half receiving the hormone Progesterone, and the half half given a placebo. The placebo group had an increased live birth rate of 57% while the Progesterone group had an impressive increase of 72%. Although the study did not provide statistics strong enough to prove it could help all women who are suffering with early bleeding, the results show a large number of women benefited from the hormone and went on to have a baby, despite their bleeding and previous miscarriage history.

Where can i get this treatment?

If you have early pregnancy bleeding, and have a history of one or more miscarriages, you can request Progesterone hormone treatment. If your health professional is not aware of this new research, you can point them to Tommy’s  who have graphics and clear information which highlights the benefits of this treatment. The evidence has not yet been confirmed by the National Institute for Health and Care Excellence, but it is hoped NICE will update their national guidelines for women who are at risk of miscarriage.

Any vaginal fluid loss or bleeding needs to be reported to your midwife straight away. Remember not to wait as your maternity unit is open 24 hours a day- 7 days a week. For further information on pregnancy symptoms that should not be ignored, check your Wellbeing Wallet