For most people with bipolar disorder, medication plays an important role in staying well. Pregnancy naturally raises questions about what’s safe, and this is one of the areas where specialist advice is absolutely essential.
| Do not stop or change your medication without medical guidance. Abruptly stopping mood stabilisers can trigger serious episodes that carry their own risks for you and your baby. Untreated bipolar disorder in pregnancy is associated with reduced engagement with prenatal care and increased risk of complications. |
Here is a brief overview of commonly used medications in pregnancy. Every case is individual — these are not decisions to make alone, but with a specialist who knows your history.
Lithium
Lithium is considered a gold-standard treatment for bipolar disorder. It can be used in pregnancy, but requires careful monitoring as lithium levels fluctuate significantly during pregnancy and regular blood tests are needed. There is a small increased risk of heart defects, though the absolute risk remains low, and many people continue lithium safely throughout pregnancy with close supervision.
Lamotrigine
Another option considered by some specialists during pregnancy. Its levels in the blood also change significantly in pregnancy and will need close monitoring with dose adjustments.
Sodium Valproate
| Sodium Valproate is contraindicated in pregnancy due to serious risks of congenital abnormalities and developmental difficulties in the baby. The MHRA has issued clear guidance on this. If you are currently on valproate and are pregnant or planning a pregnancy, speak to your doctor urgently about alternatives. |
Quetiapine and other antipsychotics
These may sometimes be used in pregnancy and carry their own specific risk profiles that your psychiatrist will discuss with you individually.